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Corneal laser surgery

Risks and side effects of laser eye surgery

Laser refractive surgery is one of the best documented procedures in the world. Its risks are real and known, most often transient or avoidable through careful candidate selection.

The essentials about laser refractive risks

  • Common transient side effects : dry eye (20 to 55% of cases), night halos, visual fluctuations. Generally resolved in three to six months.
  • Most feared complication : corneal ectasia (0.04 to 0.6% of cases), linked to a pre-existing corneal fragility undetected at examination.
  • Infection (keratitis) : exceptional, less than 0.02% of cases thanks to antibiotic protocols.
  • Global satisfaction rate : above 95% in correctly selected populations.
  • Main safety factor : a rigorous preoperative examination (topography, pachymetry, tear film) that eliminates at-risk profiles.
  • Absolute contraindications : keratoconus, cornea too thin, unstable correction, pregnancy, minors, active autoimmune diseases.
What the medical literature says

Common side effects

Dry eye

This is the most common side effect after Femto-LASIK. Creating the flap severs superficial corneal nerves, temporarily reducing corneal sensitivity and reflex tear production. Postoperative dry eye affects 20 to 55% of patients depending on the studies, but in the vast majority of cases is transient and resolves in three to six months with appropriate treatment.[1]

PRK, which treats the surface, affects corneal innervation less. It is preferred in case of pre-existing dryness.

Night halos and glare

Almost universal in the first postoperative weeks, they correspond to light diffraction at the transition zone between treated and untreated cornea. They diminish progressively as the cornea heals and the brain adapts. At three months, they are residual or absent for the majority of patients.[2]

Their persistence beyond six months is possible, particularly for larger corrections or wide pupils in scotopic conditions.

Transient visual fluctuations

In the first weeks, vision can vary with the time of day, fatigue or hydration. It is a normal phase of corneal healing. It generally stabilises in one to three months for Femto-LASIK, in three to six months for PRK.

Regression

A slight loss of the correction achieved can occur in the months or years following surgery, particularly for high myopia. It is generally minimal and can be treated with a laser enhancement if needed.[3]

Serious risks: rare but real

Corneal ectasia

This is the most feared complication. It corresponds to a progressive thinning and deformation of the cornea after laser ablation, similar to keratoconus. It occurs mainly in patients with pre-existing corneal fragility undetected during the exam, or insufficient residual thickness.[4]

Its frequency is estimated at 0.04 to 0.6% of cases depending on the populations studied. It is largely predictable and avoidable with a rigorous topographic exam. This is the main reason why corneal topography is the most important test of the preoperative exam.

Flap complications (Femto-LASIK)

Flap folds, traumatic displacement, irregular interface. These complications are rare since the introduction of the femtosecond laser (less than 1% in total) and in the majority of cases treatable.[5]

Infection (infectious keratitis)

Exceptional thanks to systematic antibiotic protocols. Its frequency is estimated at less than 0.02% of cases in centres respecting sterilisation and postoperative prescription standards.

Corneal haze (PRK)

A slight superficial opacification of the cornea can occur after PRK, especially for larger corrections. The application of mitomycin C at the end of the procedure has significantly reduced this risk. It remains possible in cases of overcorrection or atypical healing.[6]

What the preoperative exam helps avoid

The vast majority of serious complications of laser surgery are avoidable through a rigorous exam. Corneal topography detects pre-existing fragility. Pachymetry evaluates the available tissue reserve. Tear film assessment identifies dryness to be treated before surgery.

A thoroughly performed complete exam rules out the vast majority of at-risk profiles before surgery is even considered. That is its main role.

Satisfaction rateIn studies on selected populations, the satisfaction rate after laser refractive surgery exceeds 95%. It depends on rigorous candidate selection and realistic expectations.[7]

References

  1. Shoja MR, Besharati MR. Dry eye after LASIK for myopia. Eur J Ophthalmol. 2007;17(1):1-6.
  2. Eydelman M, Hilmantel G, Tarver ME, et al. Symptoms and Satisfaction of Patients in the Patient-Reported Outcomes With Laser In Situ Keratomileusis (PROWL) Studies. JAMA Ophthalmol. 2017;135(1):13-22. doi:10.1001/jamaophthalmol.2016.4587.
  3. Alio JL, et al. LASIK regression and enhancement. J Refract Surg. 2008;24(6):601-612.
  4. Binder PS. Analysis of ectasia after laser in situ keratomileusis. J Cataract Refract Surg. 2007;33(9):1530-1538.
  5. dos Santos AM, Torricelli AA, Marino GK, Garcia R, Netto MV, et al. Femtosecond Laser-Assisted LASIK Flap Complications. J Refract Surg. 2016;32(1):52-59. doi:10.3928/1081597X-20151119-01.
  6. Majmudar PA, Schallhorn SC, Cason JB, et al. Mitomycin-C in corneal surface excimer laser ablation techniques: a report by the American Academy of Ophthalmology. Ophthalmology. 2015;122(6):1085-1095. doi:10.1016/j.ophtha.2015.01.019.
  7. Solomon KD, et al. LASIK World Literature Review: quality of life and patient satisfaction. Ophthalmology. 2009;116(4):691-701.
Frequently asked

What patients often ask

Is dry eye after laser surgery permanent?

No, in the vast majority of cases. It generally resolves in three to six months with appropriate treatment.

Is corneal ectasia after laser common?

No. Its frequency is estimated between 0.04 and 0.6% of cases. It occurs mainly in patients with undetected pre-existing corneal fragility.

Do night halos after laser disappear?

Yes, for the vast majority of patients. At three months, they are residual or absent for most.

Related pages

Learn more

In perspective

Risks and benefits: what the data say

International literature is clear: laser refractive surgery is one of the best documented surgical procedures in the world. Irreversible loss of two lines of acuity or more is measured at 0.61% in the Sandoval 2016 meta-analysis (67,893 eyes).

The vast majority of reported side effects, such as halos, night glare and transient dryness, are moderate and regress within a few weeks to a few months. They occur more frequently in patients operated outside strict eligibility criteria, which underlines the importance of a rigorous preoperative exam.

What this really changes

The importance of the preoperative exam

Almost all severe complications of laser surgery occur in patients who should not have been operated on: cornea too thin, early keratoconus undetected, unstable correction. The preoperative exam's role is precisely to rule out these profiles before any surgical decision.

A rigorous exam, including corneal topography, pachymetry, aberrometry and tear film analysis, is the main protection against surgical risk. It also helps tailor the technique (Femto-LASIK vs PRK) and laser parameters to each individual profile.

Dr Serdal Sanak, ophthalmic surgeon
Author of this page
Dr Serdal Sanak
Ophthalmic surgeon · Refractive and cataract surgery
CHIREC Hôpital Delta, Brussels
Graduated from the ULB, trained at CHU de Liège and CHIREC. European Diploma in Ophthalmology (FEBO). Refractive and cataract surgery make up the bulk of my operating activity, with procedures every week at CHIREC Delta. Dual specialisation: corneal laser surgery (Femto-LASIK, PRK) and intraocular surgery (ICL, PRELEX, cataract). Consultations in French, Dutch, English, Turkish, Kurdish, Persian and Italian.
Member: ESCRS · SBO · SFO · SAFIR
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